<Suppliers Price>

(S,R,S)-AHPC-O-Ph-PEG1-NH2

Names

[ CAS No. ]:
2361117-24-8

[ Name ]:
(S,R,S)-AHPC-O-Ph-PEG1-NH2

Biological Activity

[Description]:

(S,R,S)-AHPC-O-Ph-PEG1-NH2 (VH032-O-Ph-PEG1-NH2) is E3 ligase ligand-linker conjugate and incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. (S,R,S)-AHPC-O-Ph-PEG1-NH2 is used in PROTAC EED degrader-1 (HY-130614). PROTAC EED degrader-1 is a PROTAC targeting EED with a pKD of 9.02 [1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate

[Target]

VHL


[References]

[1]. Hsu JH, et al. EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 Complex. Cell Chem Biol. 2019 Nov 26. pii: S2451-9456(19)30362-9.

Chemical & Physical Properties

[ Molecular Formula ]:
C32H41N5O6S

[ Molecular Weight ]:
623.76

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds