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Neogrifolin

Names

[ CAS No. ]:
23665-96-5

[ Name ]:
Neogrifolin

[Synonym ]:
neogrifolin
5-Methyl-4-((2E,6E)-3,7,11-trimethyl-dodeca-2,6,10-trienyl)-benzene-1,3-diol

Biological Activity

[Description]:

Neogrifolin is an inhibitor of KRAS. Neogrifolin suppress KRAS expression in human colon cancer cells. Neogrifolin has anti-cell viability activity against HeLa, SW480 and HT29 cells wih IC50s of 24.3, 34.6, and 30.1 μM, respectively[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> GPCR/G Protein >> Ras

[References]

[1]. Yaqoob A, et al. Grifolin, neogrifolin and confluentin from the terricolous polypore Albatrellus flettii suppress KRAS expression in human colon cancer cells. PLoS One. 2020 May 5;15(5):e0231948.  

Chemical & Physical Properties

[ Molecular Formula ]:
C22H32O2

[ Molecular Weight ]:
328.49

[ Exact Mass ]:
328.24000

[ PSA ]:
40.46000

[ LogP ]:
6.36790

Related Compounds