Damascenone

Names

[ Name ]:
Damascenone

[Synonym ]:
3,5,8-Megastigmatrien-7-one
MFCD00101024
FEMA 3420
Fema no. 3420
2-Buten-1-one, 1-(2,6,6-trimethyl-1,3-cyclohexadien-1-yl)-
Einecs 245-833-2
1-(2,6,6-Trimethyl-1,3-cyclohexadien-1-yl)-2-buten-1-one
DAMASCENON
Damasione
Trimethyl cyclohexadienyl butenone
DAMASCENONE TOTAL

Biological Activity

[Description]:

Damascenone ((E/Z)-Damascenone) is an active compound of Epipremnum pinnatum with anti-inflammatory activity[1]. Damascenone is a mixture complex of E-isomer-Damascenone and Z-isomer Damascenone.

[Related Catalog]:

Research Areas >> Inflammation/Immunology

[In Vitro]

β-Damascenone also inhibits the upregulation of inflammatory proteins as demonstrated by immune assays for cell surface E-selectin and secreted TNF-α[1]. β-Damascenone inhibits NF-κB signaling pathway in vitro in human cellular systems that has been activated with different inflammatory stimuli[1].

[References]

[1]. San-Po Pan, et al. C13 Megastigmane Derivatives From Epipremnum pinnatum: β-Damascenone Inhibits the Expression of Pro-Inflammatory Cytokines and Leukocyte Adhesion Molecules as Well as NF-κB Signaling

Chemical & Physical Properties

[ Density]:
0.9±0.1 g/cm3

[ Boiling Point ]:
275.6±10.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₃H₁₈O

[ Molecular Weight ]:
190.281

[ Flash Point ]:
111.0±14.0 °C

[ Exact Mass ]:
190.135757

[ PSA ]:
17.07000

[ LogP ]:
4.04

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.491

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS02, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H317-H319

[ Precautionary Statements ]:
P210-P280-P305 + P351 + P338-P370 + P378-P403 + P235

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
F: Flammable;

[ Risk Phrases ]:
R11

[ Safety Phrases ]:
S7-S16

[ RIDADR ]:
UN 1170

[ HS Code ]:
2914299000

Customs

[ HS Code ]: 2914299000

[ Summary ]:
2914299000. other cyclanic, cyclenic or cyclotherpenic ketones without other oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

Articles

Instrumental and sensory approaches for the characterization of compounds responsible for wine aroma.

Chem. Biodivers. 5(6) , 1170-83, (2008)

More than 800 aromatic compounds have been identified in wine, some of them at the ng/l level. Wine, therefore, constitutes a very complex matrix, from which it is difficult to isolate a specific arom...

Identification and quantification of aroma-active components that contribute to the distinct malty flavor of buckwheat honey.

J. Agric. Food Chem. 50(7) , 2016-21, (2002)

Characteristic aroma components of buckwheat honey were studied by combined sensory and instrumental techniques. Relative aroma intensity of individual volatile components was evaluated by aroma extra...

Simultaneous determination of E-2-nonenal and beta-damascenone in beer by reversed-phase liquid chromatography with UV detection.

J. Chromatogr. A. 1032(1-2) , 17-22, (2004)

A method for the simultaneous determination of E-2-nonenal and beta-damascenone in beer by reversed-phase liquid chromatography using UV detection is presented. The method consists of beer steam disti...