8H-Benzo[g]-1,3-benzodioxolo[6,5,4-de]quinolin-8-one,10-methoxy-

Names

[ Name ]:
8H-Benzo[g]-1,3-benzodioxolo[6,5,4-de]quinolin-8-one,10-methoxy-

[Synonym ]:
10-Methoxy-8H-benzo[g]-1,3-benzodioxolo[6,5,4-de]quinolin-8-one
Oxoxylopine
10-methoxy-benzo[g][1,3]dioxolo[4',5':4,5]benzo[1,2,3-de]quinolin-8-one
9-METHOXY-1,2-METHYLENEDIOXY-7-OXAPORPHINE

Biological Activity

[Description]:

Lanuginosine (Compound 12) is an AChE inhibitor (IC50: 10.9 μM). Lanuginosine inhibits Aβ aggregation. Lanuginosine can be used for research of Alzheimer’s disease[1].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> Neuronal Signaling >> AChE

[Target]

10.9 μM (AChE)[1]

[References]

[1]. Jiang K, et al. Bioactive Isoquinoline Alkaloids with Diverse Skeletons from Fissistigma polyanthum. J Nat Prod. 2023 Aug 24.

Chemical & Physical Properties

[ Density]:
1.472g/cm3

[ Boiling Point ]:
572.5ºC at 760mmHg

[ Molecular Formula ]:
C₁₈H₁₁NO₄

[ Molecular Weight ]:
305.28

[ Flash Point ]:
300.1ºC

[ Exact Mass ]:
305.06900

[ PSA ]:
57.65000

[ LogP ]:
3.18350

[ Vapour Pressure ]:
4.07E-13mmHg at 25°C

[ Index of Refraction ]:
1.729

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RB6035500

CHEMICAL NAME :: Noraporphin-7-one, 4,5,6,6a-tetradehydro-9-methoxy-1,2-(methylenedioxy)-

CAS REGISTRY NUMBER :: 23740-25-2

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C18-H11-N-O4

MOLECULAR WEIGHT :: 305.30

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 3 ug/plate

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 240,267,1990

Safety Information

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%