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DCN1-UBC12-IN-1

Names

[ CAS No. ]:
2374827-31-1

[ Name ]:
DCN1-UBC12-IN-1

Biological Activity

[Description]:

DCN1-UBC12-IN-1 is potent and selective DCN1-UBC12 inhibitor with an IC50 of 2.86 nM. Anticardiac fibrotic effect[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Metabolic Enzyme/Protease >> E1/E2/E3 Enzyme

[In Vitro]

DCN1-UBC12-IN-1 (compound 44) possesses low cytotoxicity toward cardiac fibroblasts (CFs) with an IC50 of 9.97 μM for 24 h[1].

[References]

[1]. He ZX, et al. Discovery of Potent and Selective 2-(Benzylthio)pyrimidine-based DCN1-UBC12 Inhibitors for Anticardiac Fibrotic Effects. J Med Chem. 2022;65(1):163-190.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₄H₂₃N₇O₃S₂

[ Molecular Weight ]:
521.61

Related Compounds