Ac-FLTD-CMK
Names
[ CAS No. ]:
2376255-48-8
[ Name ]:
Ac-FLTD-CMK
Biological Activity
[Description]:
Ac-FLTD-CMK, a gasdermin D (GSDMD)-derived inhibitor, is a specific inflammatory caspases inhibitor. Ac-FLTD-CMK is effective against caspases-1 (IC50 of 46.7 nM), caspases-4 (IC50 of 1.49 μM), caspases-5 (IC50 of 329 nM), and caspases-11 , but not the apoptotic caspases such as caspase-3[1].
[Related Catalog]:
[Target]
Caspase-1:46.7 nM (IC50)
Caspase-4:1.49 μM (IC50)
Caspase-5:329 nM (IC50)
Caspase-11
[In Vitro]
Ac-FLTD-CMK, inhibits GSDMD cleavage by caspases-1, -4, -5, and -11 in vitro, suppresses pyroptosis downstream of both canonical and noncanonical inflammasomes, as well as reduces IL-1β release following activation of the NLRP3 inflammasome in macrophages. By contrast, Ac-FLTD-CMK does not target caspase-3 or apoptotic cell death. Crystal structure of caspase-1 in complex with Ac-FLTD-CMK reveals extensive enzyme-inhibitor interactions involving both hydrogen bonds and hydrophobic contacts[1].
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C26H37ClN4O8
[ Molecular Weight ]:
569.05
Safety Information
[ Hazard Codes ]:
Xi