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Thalidomide-O-amido-C6-NH2 hydrochloride

Names

[ CAS No. ]:
2376990-31-5

[ Name ]:
Thalidomide-O-amido-C6-NH2 hydrochloride

Biological Activity

[Description]:

Thalidomide-O-amido-C6-NH2 hydrochloride, a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate

[Target]

Cereblon


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. Bradner J, et al. Targeted protein degradation to attenuate adoptive t-cell therapy associated adverse inflammatory responses. WO 2017024318 A1

Chemical & Physical Properties

[ Molecular Formula ]:
C21H27ClN4O6

[ Molecular Weight ]:
466.92

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds