AGI-43192

Names

[ Name ]:
AGI-43192

Biological Activity

[Description]:

AGI-43192 is a potent inhibitor of methionine adenosyltransferase 2A (MAT2A). AGI-43192 is a potent, but limited brain-penetrant compound. AGI-43192 has the potential for exploring the effects of SAM modulation in the central nervous system (CNS) and research of cancer disease[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> GPCR/G Protein >> Somatostatin Receptor

Research Areas >> Neurological Disease

[References]

[1]. Li M, et al. Leveraging Structure-Based Drug Design to Identify Next-Generation MAT2A Inhibitors, Including Brain-Penetrant and Peripherally Efficacious Leads. J Med Chem. 2022;65(6):4600-4615.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₁₆ClF₃N₆O

[ Molecular Weight ]:
484.86

AGI-43192

Names

Biological Activity

Chemical & Physical Properties

Related Compounds