8-(Trifluoromethyl)-4-quinolinol

Names

[ Name ]:
8-(Trifluoromethyl)-4-quinolinol

[Synonym ]:
8-trifluoromethyl-quinolin-4-ol
4-Hydroxy-8-(trifluoromethyl)quinoline
4-Hydroxy-8-trifluormethyl-chinolin
8-(Trifluoromethyl)-4-quinolinol
8-(Trifluoromethyl)quinolin-4(1H)-one
8-(trifluoromethyl)quinolin-4-ol
EINECS 245-879-3
MFCD00134577
8-trifluoromethyl-4-hydroxyquinoline
4-hydroxy-8-trifluoromethylquinoline
4-Quinolinol, 8-(trifluoromethyl)-

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
311.9±37.0 °C at 760 mmHg

[ Melting Point ]:
174-176 °C(lit.)

[ Molecular Formula ]:
C₁₀H₆F₃NO

[ Molecular Weight ]:
213.156

[ Flash Point ]:
142.4±26.5 °C

[ Exact Mass ]:
213.040146

[ PSA ]:
33.12000

[ LogP ]:
2.86

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.574

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2933499090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933499090

[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Design, synthesis and docking studies of new quinoline-3-carbohydrazide derivatives as antitubercular agents.

Eur. J. Med. Chem. 46 , 5283-92, (2011)

Three new series of 4-hydroxy-8-trifluoromethyl-quinoline derivatives were synthesized through multi step reactions. All the newly synthesized compounds were characterized by spectral and elemental an...

William Andrew Publishing

Pharmaceutical Manufacturing Encyclopedia , (2013) 4 , 1621