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K-Ras ligand-Linker Conjugate 4

Names

[ CAS No. ]:
2378261-83-5

[ Name ]:
K-Ras ligand-Linker Conjugate 4

Biological Activity

[Description]:

K-Ras ligand-Linker Conjugate 4 incorporates a ligand for K-Ras recruiting moiety, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 4 can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523), which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells[1].

[Related Catalog]:

Research Areas >> Cancer

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. CREW, Andrew P., et al. MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE. WO2019195609A2.

Chemical & Physical Properties

[ Molecular Formula ]:
C35H51N7O8

[ Molecular Weight ]:
697.82

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds