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ENPP1 Inhibitor C

Names

[ CAS No. ]:
2378640-92-5

[ Name ]:
ENPP1 Inhibitor C

[Synonym ]:
ENPP1 Inhibitor C
6-(3-Aminobenzyl)-N,N,5-trimethyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
[1,2,4]Triazolo[1,5-a]pyrimidin-7-amine, 6-[(3-aminophenyl)methyl]-N,N,5-trimethyl-

Biological Activity

[Description]:

Enpp-1-IN-2 (Compound C) is a potent ENPP1 (ectonucleotide pyrophosphatase/phosphodiesterase 1) inhibitor with IC50 values of 0.26, 0.48 and 2.0 μM evaluated by means of TG-mAMP, pNP-TMP, and ATP assays, respectively. TG (Tokyo Green)-mAMP: a newly synthesized sensitive ENPP1 fluorescence probe[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE)

[Target]

IC50: 0.26 μM (TG-mAMP assay), 0.48 μM (pNP-TMP assay), 2.0 μM (ATP assay)[1]


[References]

[1]. Kawaguchi M, et al. Development of an ENPP1 Fluorescence Probe for Inhibitor Screening, Cellular Imaging, and Prognostic Assessment of Malignant Breast Cancer. J Med Chem. 2019 Oct 24;62(20):9254-9269.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Molecular Formula ]:
C15H18N6

[ Molecular Weight ]:
282.344

[ Exact Mass ]:
282.159302

[ LogP ]:
1.10

[ Index of Refraction ]:
1.679

Related Compounds