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Nampt-IN-5

Names

[ CAS No. ]:
2380013-17-0

[ Name ]:
Nampt-IN-5

Biological Activity

[Description]:

Nampt-IN-5 is a potent and orally active nicotinamide phosphoribosyltransferase (NAMPT) inhibitor. Nampt-IN-5 inhibits CYP3A4 activity and has cellular IC50s of 0.7 nM and 3.9 nM against A2780 and COR-L23, respectively[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> Nampt

[Target]

IC50: Nampt[1]


[In Vitro]

Nampt-IN-5 (0-10 nM; 3 days) has cellular IC50s of 0.7 nM and 3.9 nM against A2780 and COR-L23, respectively in CellTiterGlo (CTG) assays[1]. Nampt-IN-5 shows a good ADME data: mouse microsomal clearance (110 μl/min*mg), CYP3A4 inhibition value (0.75 μM), Sol6.8: 0.056 mM; MDCK Papp AB: 18.6[1].

[References]

[1]. Palacios DS, et al. Scaffold Morphing Identifies 3-Pyridyl Azetidine Ureas as Inhibitors of Nicotinamide Phosphoribosyltransferase (NAMPT).ACS Med Chem Lett. 2019 Oct 10;10(11):1524-1529.

Chemical & Physical Properties

[ Molecular Formula ]:
C25H25N5O2

[ Molecular Weight ]:
427.50

[ Storage condition ]:
2-8°C

Related Compounds