Pomalidomide-PEG1-NH2-1 hydrochloride

Names

[ CAS No. ]:
2380273-67-4

[ Name ]:
Pomalidomide-PEG1-NH2-1 hydrochloride

Biological Activity

[Description]:

Pomalidomide-PEG1-NH2 hydrochloride is a crosslinker-E3 ligase ligand conjugate, consisting of an E3 ligase ligand pomalidomide and a PEGylated crosslinker with terminal amine for reactivity with a carboxyl group on the target ligand[1].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate

[References]

[1]. Lee B, et al. Synthesis and discovery of the first potent proteolysis targeting chimaera (PROTAC) degrader of AIMP2-DX2 as a lung cancer drug. J Enzyme Inhib Med Chem. 2023 Dec;38(1):51-66.  

Chemical & Physical Properties

[ Molecular Formula ]:
C17H19ClN4O6

[ Molecular Weight ]:
410.81

Related Compounds