CDK4/6-IN-5

Names

[ Name ]:
CDK4/6-IN-5

Biological Activity

[Description]:

CDK4/6-IN-5 is a potent CDK4 and CDK6 inhibitor with Kis of 0.2 and 4.4 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively[1]. (from patent WO2019207463A1 example A93).

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> CDK

[In Vitro]

The CDK4 and CDK6 cell-based IC50s of CDK4/6-IN-5 in JEKO-1 and MV4-1 1 cells are 23.8 and 61.4 nM, respectively[1].

[References]

[1]. Ping Chen, et al. 2-amino-pyridine or 2-amino-pyrimidine derivatives as cyclin dependent kinase inhibitors. WO2019207463A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₂₈ClFN₆O₄S

[ Molecular Weight ]:
527.01

CDK4/6-IN-5

Names

Biological Activity

Chemical & Physical Properties

Related Compounds