Hyperforin dicyclohexylammonium salt

Names

[ Name ]:
Hyperforin dicyclohexylammonium salt

[Synonym ]:
hyperforin dicyclohexylammonium salt
Hyp-DCHA Hyperforin-DCHA
Hyp-DCHA
Hyperforin-DCHA

Biological Activity

[Description]:

Hyperforin dicyclohexylammonium salt (Hyperforin DCHA) is a transient receptor canonical 6 (TRPC6) channels activator. Hyperforin dicyclohexylammonium salt modulates Ca2+ levels by activating Ca2+-conducting non-selective canonical TRPC6 channels. Hyperforin dicyclohexylammonium salt shows antidepressant effect[1][2].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel

Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel

Research Areas >> Neurological Disease

[In Vitro]

Hyperforin dicyclohexylammonium salt (Hyperforin DCHA) has a multi-directional mechanism of action. It blocks conductance of ligand-gated (GABA, NMDA, and AMPA receptors) and voltage-gated channels (Ca2+, K+, and Na+)[2].

[References]

[1]. Heiser JH, et al. TRPC6 channel-mediated neurite outgrowth in PC12 cells and hippocampal neurons involves activation of RAS/MEK/ERK, PI3K, and CAMKIV signaling. J Neurochem. 2013 Nov;127(3):303-13.

[2]. Pochwat B, et al. Hyperforin Potentiates Antidepressant-Like Activity of Lanicemine in Mice. Front Mol Neurosci. 2018 Dec 12;11:456.

Chemical & Physical Properties

[ Molecular Formula ]:
C₄₇H₇₅NO₄

[ Molecular Weight ]:
718.10300

[ Exact Mass ]:
717.57000

[ PSA ]:
83.47000

[ LogP ]:
12.62200

Safety Information

[ Symbol ]:

GHS05, GHS07, GHS09

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H314-H400

[ Precautionary Statements ]:
P273-P280-P305 + P351 + P338-P310

[ RIDADR ]:
UN 1759 8 / PGIII

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