Bradykinin Fragment 1-7

Names

[ Name ]:
Bradykinin Fragment 1-7

[Synonym ]:
des-phe(8)-des-arg(9)-bradykini
H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-OH
MFCD00076262
BRADYKININ FRAGMENT 1-7
BRADYKININ (1-7)
RPPGFSP
Arg-Pro-Pro-Gly-Phe-Ser-Pro-OH
bradykinin,des-Phe(8)-des-Arg(9)
ARG-PRO-PRO-GLY-PHE-SER-PRO ACETATE
BRADYKININ 1-7 ACETATE
ARG-PRO-PRO-GLY-PHE-SER-PRO
Bradykinin: 1-7

Biological Activity

[Description]:

Bradykinin (1-7) is an amino-truncated Bradykinin peptide. Bradykinin (1-7) is a metabolite of Bradykinin, cleaved by endopeptidase.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Bradykinin Receptor

Peptides

Research Areas >> Cardiovascular Disease

[In Vitro]

The Bradykinin peptide system is a tissue-based system with potent cardiovascular and renal effects. To investigate the regulation of this system, a highly sensitive amino terminal-directed radioimmunoassay that, with high performance liquid chromatography, enables the measurement of Bradykinin-(1-7), Bradykinin-(1-8), and Bradykinin-(1-9), is developed. Together with a carboxy terminal-directed radioimmunoassay, Bradykinin peptides in rat kidney and blood are characterized. The predominant Bradykinin peptides in kidney are Bradykinin-(1-9) (~100 fmol/g wet weight of tissue) and Bradykinin-(1-7) (~70 fmol/g), with low levels of Bradykinin-(1-8) (~8 fmol/g) and Bradykinin-(4-9) (~12 fmol/g) detectable; Bradykinin-(2-9) and Bradykinin-(3-9) are below the limits of detection. In blood, the levels of Bradykinin-(1-9) are very low (~2 fmol/ml), and other Bradykinin peptides are below the limits ofdetection. Administration of the angiotensin converting enzyme (ACE) inhibitor Perindopril is associated with an approximate twofold increase in renal levels of Bradykinin-(1-8) and Bradykinin-(1-9) and a decrease in the Bradykinin-(1-7)/Bradykinin-(1-9) ratio. The amino terminal-directed radioimmunoassay is also applied to heart, aorta, brown adipose tissue, adrenal, lung, and brain. For these tissues, Bradykinin-(1-7) and Bradykinin-(1-9) are of similar abundance (16-340 fmol/g), with lower levels of Bradykinin-(1-8)[1].

[References]

[1]. Campbell DJ, et al. Bradykinin peptides in kidney, blood, and other tissues of the rat. Hypertension. 1993 Feb;21(2):155-65.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.52 g/cm3

[ Molecular Formula ]:
C₃₅H₅₂N₁₀O₉

[ Molecular Weight ]:
756.84900

[ Exact Mass ]:
756.39200

[ PSA ]:
293.68000

[ Index of Refraction ]:
1.695

[ Storage condition ]:
−20°C

[ Water Solubility ]:
Soluble in water (1 mg/ml).

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
F+

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Ixodes scapularis: salivary kininase activity is a metallo dipeptidyl carboxypeptidase.

Exp. Parasitol. 89 , 213-21, (1998)

Saliva and salivary gland homogenates of Ixodes scapularis contain a dipeptidyl carboxypeptidase activity that accounts for the previously described salivary kininase activity of this tick. Reversed p...

Bradykinin is not involved in angiotensin converting enzyme modulation of ovarian steroidogenesis and prostaglandin production in frog Rana esculenta.

Acta Physiol. Scand. 175 , 123-128, (2002)

Angiotensin converting enzyme (ACE) was demonstrated to modulate the production of 17beta-estradiol, progesterone and prostaglandin E2 (PGE2) in frog ovary of Rana esculenta. However, the activity was...

Purification and characterization of bioactive peptides from skin extracts of Rana esculenta.

Biochim. Biophys. Acta 1033 , 318-323, (1990)

The peptide fraction extracted by methanol from the skin of Rana esculenta, a species widely distributed in Western Europe, was investigated. The pharmacological activity found in the extract is attri...