Eritadenine

Names

[ Name ]:
Eritadenine

[Synonym ]:
Lentysine
d-4-(6-amino-9h-purin-9-yl)-4-deoxyerythronicacid
d-erythronicaci
lentinacin
2(R),3(R)-dihydroxy-4-(9-adenyl)butyric acid
D-eritadenine acid
4-(6-AMinopurin-9-yl)-4-deoxy-D-erythronic Acid
4-(6-amino-purin-9-yl)-2,3-dihydroxy-butyric acid
4-(6-AMino-9H-purin-9-yl)-4-deoxy-D-erythronic Acid
D-Eritadenine
AA-307
eritadenine

Biological Activity

[Description]:

Eritadenine (Lentinacin) is a S-adenosyl-L-homocysteine hydrolase (SAHH) inhibitor. Eritadenine can be found in secondary metabolites of shiitake mushrooms. Eritadenine lowers blood cholesterol levels and can be used in cardiovascular disease research[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

[Target]

SAHH[1][2].

[References]

[1]. Yamada T, et al. Structure and function of eritadenine and its 3-deaza analogues: potent inhibitors of S-adenosylhomocysteine hydrolase and hypocholesterolemic agents. Biochem Pharmacol. 2007 Apr 1;73(7):981-9.

[2]. Morales D, et al. Effect of traditional and modern culinary processing, bioaccessibility, biosafety and bioavailability of eritadenine, a hypocholesterolemic compound from edible mushrooms. Food Funct. 2018 Dec 13;9(12):6360-6368.

Chemical & Physical Properties

[ Density]:
1.92g/cm3

[ Boiling Point ]:
721.3ºC at 760 mmHg

[ Molecular Formula ]:
C₉H₁₁N₅O₄

[ Molecular Weight ]:
253.21

[ Flash Point ]:
390ºC

[ Exact Mass ]:
253.08100

[ PSA ]:
147.38000

[ Vapour Pressure ]:
7.75E-22mmHg at 25°C

[ Index of Refraction ]:
1.823

[ Storage condition ]:
2-8°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KF5798000

CHEMICAL NAME :: Erythronic acid, 4-(6-amino-9H-purin-9-yl)-4-deoxy-, D-

CAS REGISTRY NUMBER :: 23918-98-1

LAST UPDATED :: 199509

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C9-H11-N5-O4

MOLECULAR WEIGHT :: 253.25

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TEST SYSTEM :: Insect - Drosophila melanogaster

DOSE/DURATION :: 100 ppm

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 311,305,1994

Safety Information

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%