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PD-1/PD-L1-IN 6

Names

[ CAS No. ]:
2393983-76-9

[ Name ]:
PD-1/PD-L1-IN 6

Biological Activity

[Description]:

PD-1/PD-L1-IN 6 (compound A13) is a potent PD-1/PD-L1 interaction inhibitor, with an IC50 of 132.8 nM. PD-1/PD-L1-IN 6 exhibits outstanding immunoregulatory activity. PD-1/PD-L1-IN 6 significantly elevates interferon-γ secretion in a Hep3B/OS-8/hPD-L1 and CD3 T cell co-culture model, without significant toxic effect. PD-1/PD-L1-IN 6 restores the immune response in a T cell-tumor co-culture model[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Immunology/Inflammation >> PD-1/PD-L1
Research Areas >> Inflammation/Immunology

[Target]

IC50: 132.8 ± 6.9 nM (PD-1/PD-L1 interaction)


[References]

[1]. Qin M, et al. Discovery of the programmed cell death-1/programmed cell death-ligand 1 interaction inhibitors bearing an indoline scaffold. Eur J Med Chem. 2020 Jan 15;186:111856.

Chemical & Physical Properties

[ Molecular Formula ]:
C25H26N2O3

[ Molecular Weight ]:
402.49

Related Compounds