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Meranzin

Names

[ CAS No. ]:
23971-42-8

[ Name ]:
Meranzin

[Synonym ]:
pimelic acid monomethyl ester
8-{[(2S)-3,3-Dimethyl-2-oxiranyl]methyl}-7-methoxy-2H-chromen-2-one
6-methoxycarbonylhexanoic acid
methyl hydrogenpimelate
monomethyl heptanedioate
Heptanedioic acid,1-methyl ester
2H-1-Benzopyran-2-one, 8-[[(2S)-3,3-dimethyloxiranyl]methyl]-7-methoxy-
Heptanedioic acid,monomethyl ester
Methyl hydrogen heptane-1,7-dioate
Monomethyl pimelate

Biological Activity

[Description]:

Meranzin is an absorbed bioactive compound from the Traditional Chinese Medicine (TCM) Chaihu-Shugan-San (CSS). Meranzin, isolated from leaves of Murraya exotica L., regulates the shared alpha 2-adrenoceptor and involves the AMPA-ERK1/2–BDNF signaling pathway. Meranzin has the potential for the prevention of the comorbidity of atherosclerosis and depression[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor
Research Areas >> Neurological Disease

[References]

[1]. Lan Li, et al. Chaihu-Shugan-San and Absorbed Meranzin Hydrate Induce Anti-Atherosclerosis and Behavioral Improvements in High-Fat Diet ApoE -/- Mice via Anti-Inflammatory and BDNF-TrkB Pathway. Biomed Pharmacother. 2019 Jul;115:108893.

[2]. Rongwei Yan, et al. Preparative Isolation and Purification of Hainanmurpanin, Meranzin, and Phebalosin From Leaves of Murraya Exotica L. Using Supercritical Fluid Extraction Combined With Consecutive High-Speed Countercurrent Chromatography. J Sep Sci. 2018 May;41(9):2092-2101.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
414.8±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C15H16O4

[ Molecular Weight ]:
260.285

[ Flash Point ]:
185.3±28.8 °C

[ Exact Mass ]:
260.104858

[ PSA ]:
51.97000

[ LogP ]:
1.92

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.567

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds