7,27-dihydroxycholesterol

Names

[ Name ]:
7,27-dihydroxycholesterol

[Synonym ]:
5-cholesten-3β,7β,27-triol

Biological Activity

[Description]:

7ß,27-Dihydroxycholesterol (7β, 27-OHC) is a potent and selective activator of RORγt (Ki=120 nM). 7ß,27-Dihydroxycholesterol promotes the differentiation of mouse and human CD4+ Th17 cells. 7ß,27-Dihydroxycholesterol also increases the production of IL-17 depended on CYP27A1[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> ROR

Research Areas >> Inflammation/Immunology

[Target]

RORγt:120 nM (Ki)

[In Vitro]

7ß,27-Dihydroxycholesterol (0.3 μM 或 6 μM; 2 h) 在体外分别诱导人类和小鼠 Th17 细胞产生 IL-17[1]。

[In Vivo]

7ß,27-Dihydroxycholesterol (60 mg/kg;皮下注射; 每天 2 次，共 3 天) 在体内诱导小鼠产生 IL-17[1]。

[References]

[1]. Soroosh P, et al. Oxysterols are agonist ligands of RORγt and drive Th17 cell differentiation. Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):12163-8.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₇H₄₆O₃

[ Molecular Weight ]:
418.65200

[ Exact Mass ]:
418.34500

[ PSA ]:
60.69000

[ LogP ]:
5.33190

[ Storage condition ]:
-20°C

7,27-dihydroxycholesterol

Names

Biological Activity

Chemical & Physical Properties

Related Compounds