Sirt1/2-IN-1

Names

[ CAS No. ]:
2402779-21-7

[ Name ]:
Sirt1/2-IN-1

Biological Activity

[Description]:

Sirt1/2-IN-1 (Compound 7) is a SIRT1 and SIRT2 inhibitor with IC50 values of 1.81, 2.10 and 20.5 µg/mL against SIRT1, SIRT2 and SIRT3, respectively. Sirt1/2-IN-1 displays activity in hyperacetylation of α-tubulin protein with an IC50 of 32.05 µg/mL. Sirt1/2-IN-1 shows prominent anticancer activity[1].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> Sirtuin
Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Sirtuin
Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin
Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin

[Target]

SIRT1:1.81 μg/mL (IC50)

SIRT2:2.10 μg/mL (IC50)

SIRT3:20.5 μg/mL (IC50)


[References]

[1]. Khalil NA, et al. Synthesis of certain benzothieno[3,2-d]pyrimidine derivatives as a selective SIRT2 inhibitors. Eur J Med Chem. 2020 Feb 1;187:111926.

Chemical & Physical Properties

[ Molecular Formula ]:
C22H13ClN2OS2

[ Molecular Weight ]:
420.93

Related Compounds