OM-1700

Names

[ Name ]:
OM-1700

Biological Activity

[Description]:

OM-1700 is a potent tankyrase inhibitor with IC50s of 127 and 14 nM for tankyrase 1 and tankyrase 2, respectively. OM-1700 reduces cell growth in the colon cancer cell line COLO 320DM (GI50=650 nM)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Epigenetics >> PARP

Signaling Pathways >> Cell Cycle/DNA Damage >> PARP

[Target]

TNKS1:127 nM (IC50)

TNKS2:14 nM (IC50)

[In Vitro]

OM-153 shows inhibition (IC50=19 nM) in a cellular (HEK293) WNT/β-catenin signaling reporter assay[1].

[References]

[1]. Leenders RGG, et al. Development of a 1,2,4-Triazole-Based Lead Tankyrase Inhibitor: Part II. J Med Chem. 2021;64(24):17936-17949.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₅H₂₃FN₆O₂

[ Molecular Weight ]:
458.49

OM-1700

Names

Biological Activity

Chemical & Physical Properties

Related Compounds