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Imlunestrant tosylate

Names

[ CAS No. ]:
2408840-41-3

[ Name ]:
Imlunestrant tosylate

Biological Activity

[Description]:

Imlunestrant (LY-3484356) tosylate is an orally active, potent and selective estrogen receptor degrader (SERD) with pure antagonistic properties. Imlunestrant tosylate results in sustained inhibition of ER-dependent gene transcription and cell growth. Imlunestrant tosylate can be used for the research of ER-positive (ER+) advanced breast cancer (aBC) and endometrial endometrioid cancer (EEC)[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Estrogen Receptor/ERR
Research Areas >> Cancer

[In Vitro]

LY3484356 显示出良好药代动力学 (PK) 特性，包括在 ESR1 突变体中的抗肿瘤活性[1]。

[References]

[1]. Komal L. Jhaveri, et al. A first-in-human phase 1a/b trial of LY3484356, an oral selective estrogen receptor (ER) degrader (SERD) in ER+ advanced breast cancer (aBC) and endometrial endometrioid cancer (EEC): Results from the EMBER study. 2021 ASCO Annual Meeting I.

[2]. Cristina Hernando, et al. Oral Selective Estrogen Receptor Degraders (SERDs) as a Novel Breast Cancer Therapy: Present and Future from a Clinical Perspective. Int. J. Mol. Sci. 2021, 22(15), 7812.

Chemical & Physical Properties

[ Molecular Formula ]:
C36H32F4N2O6S

[ Molecular Weight ]:
696.71

Related Compounds