HDAC6-IN-11
Names
[ CAS No. ]:
2409072-27-9
[ Name ]:
HDAC6-IN-11
Biological Activity
[Description]:
HDAC6-IN-11 (Compound 9) is a selective HDAC6 inhibitor with the IC50 value of 20.7 nM. HDAC6-IN-11 has more than 300-fold selectivity over HDAC other isoforms. HDAC6-IN-11 shows anti-proliferative activities against cancer cells[1].
[Related Catalog]:
[Target]
HDAC6:20.7 nM (IC50)
HDAC8:7750 nM (IC50)
[In Vitro]
HDAC6-IN-11 (0.44-6.68 μM, 48 h) treatment shows anti-proliferative activities against A549 and HCT116 cells[1]. HDAC6-IN-11 (0-20 μM, 48 h) treatment can increase the acetylation status of H3 and tubulin[1]. Cell Proliferation Assay[1] Cell Line: A549 and HCT116 cells Concentration: 0.44-6.68 μM Incubation Time: 48 hours Result: Showed anti-proliferative activities to A549 and HCT116 cells (GI50=3.2 and 1.82 μM, respectively). Western Blot Analysis[1] Cell Line: HCT116 cells Concentration: 0, 0.6, 1.25, 2.5, 5, 10 and 20 μM Incubation Time: 48 hours Result: Led to the increase of acetylation status of H3 and tubulin in a dose-dependent manner, and upregulated acetylated tubulin.
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C19H16N2O4
[ Molecular Weight ]:
336.34