CDK2-IN-11

Names

[ CAS No. ]:
2410402-82-1

[ Name ]:
CDK2-IN-11

Biological Activity

[Description]:

CDK2-IN-11 (compound 9d) is a potent CDK2 inhibitor with an IC50 of 6.4 μM, and KI values of 23.4 nM, 56.3 nM and 44.3 nM for hCA II, hCA IX and hCA XII, respectively. CDK2-IN-11 can be used for researching anticancer[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> CDK
Signaling Pathways >> Metabolic Enzyme/Protease >> Carbonic Anhydrase

[Target]

IC50: 6.4 μM (CDK2)[1] KI: 23.4 nM (hCA II), 56.3 nM (hCA IX), 44.3 nM (hCA XII)[1]


[References]

[1]. Said MA, et al. Sulfonamide-based ring-fused analogues for CAN508 as novel carbonic anhydrase inhibitors endowed with antitumor activity: Design, synthesis, and in vitro biological evaluation. Eur J Med Chem. 2020 Mar 1;189:112019.

Chemical & Physical Properties

[ Molecular Formula ]:
C18H14ClN7O2S

[ Molecular Weight ]:
427.87

Related Compounds