5-HT6/5-HT2A receptor ligand-1

Names

[ CAS No. ]:
2411088-07-6

[ Name ]:
5-HT6/5-HT2A receptor ligand-1

Biological Activity

[Description]:

5-HT6/5-HT2A receptor ligand-1 (compound 33) is a dual 5-HT6/5-HT2A receptor antagonist, with a Ki of 2 nM and 11 nM, respectively. 5-HT6/5-HT2A receptor ligand-1 has the potential for neurological and psychiatric disorders research[1].

[Related Catalog]:

Research Areas >> Neurological Disease
Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor
Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

[Target]

5-HT6 Receptor:2 nM (Ki)

5-HT2A Receptor:11 nM (IC50)


[References]

[1]. Staroń J, et, al. Virtual screening-driven discovery of dual 5-HT 6/5-HT 2A receptor ligands with pro-cognitive properties. Eur J Med Chem. 2020 Jan 1;185:111857.

Chemical & Physical Properties

[ Molecular Formula ]:
C21H19FN2O2

[ Molecular Weight ]:
350.39

Related Compounds