KRAS inhibitor-21

Names

[ CAS No. ]:
2411786-50-8

[ Name ]:
KRAS inhibitor-21

Biological Activity

[Description]:

KRAS inhibitor-21 (22b) is a KRAS G12C inhibitor with an IC50 value of <0.01 μM. KRAS inhibitor-21 can be used in cancer research[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> GPCR/G Protein >> Ras

[References]

[1]. Kargbo RB, et al. Small-Molecule Inhibitor of the Oncogenic KRASG12C Mutant for the Treatment of Currently Incurable Cancer. ACS Med Chem Lett. 2022 Apr 20;13(5):767-769.

Chemical & Physical Properties

[ Molecular Formula ]:
C33H41N5O3

[ Molecular Weight ]:
555.71

Related Compounds