HDAC6/HSP90-IN-1

Names

[ CAS No. ]:
2411955-43-4

[ Name ]:
HDAC6/HSP90-IN-1

Biological Activity

[Description]:

HDAC6/HSP90-IN-1 (compound 17) is a potent and selective dual inhibitor of HDAC6 and HSP90, with IC50 values of 4.3 and 46.8 nM, respectively. HDAC6/HSP90-IN-1 down-regulates PD-L1 expression in INF-γ treated H1975 lung cancer cells. HDAC6/HSP90-IN-1 inhibits tumor growth in human H1975 xenograft mice[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> HSP
Signaling Pathways >> Cell Cycle/DNA Damage >> HSP
Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC
Signaling Pathways >> Epigenetics >> HDAC

[Target]

HDAC6:4.32 nM (IC50)

HSP90:46.8 nM (IC50)

HDAC3:1312 nM (IC50)

HDAC1:1878 nM (IC50)

HDAC8:3720 nM (IC50)


[References]

[1]. Ojha R, et al. Isoindoline scaffold-based dual inhibitors of HDAC6 and HSP90 suppressing the growth of lung cancer in vitro and in vivo. Eur J Med Chem. 2020 Mar 15;190:112086.

Chemical & Physical Properties

[ Molecular Formula ]:
C28H37N3O6

[ Molecular Weight ]:
511.61

Related Compounds