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Thalidomide-NH-PEG4-COOH

Names

[ CAS No. ]:
2412056-48-3

[ Name ]:
Thalidomide-NH-PEG4-COOH

Biological Activity

[Description]:

Thalidomide-NH-PEG4-COOH is an E3 ligase ligand-linker conjugate which can be used for synthesizing dCBP-1 (HY-134582). dCBP-1 is a potent and selective heterobifunctional degrader of p300/CBP[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate

[Target]

Cereblon


[In Vitro]

Thalidomide-NH-PEG4-COOH (S13) is the E3 ligase ligand-linker conjugate of dCBP-1 (HY-134582)[1].

[References]

[1]. Raghu Vannam, et al. Targeted degradation of the enhancer lysine acetyltransferases CBP and p300. Cell Chem Biol. 2020 Dec 31;S2451-9456(20)30513-4.

Chemical & Physical Properties

[ Molecular Formula ]:
C24H31N3O10

[ Molecular Weight ]:
521.52

[ Storage condition ]:
-20°C

Related Compounds