hCAXII-IN-4

Names

[ CAS No. ]:
2414601-79-7

[ Name ]:
hCAXII-IN-4

Biological Activity

[Description]:

hCAXII-IN-4 (compound 5j) is a potent and selective CA XII inhibitor with an Ki value of 6.4 nM for human CA XII[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> Carbonic Anhydrase

[Target]

Ki: 129.8 nM (hCAI), 40.7 nM (hCAII), 45.3 nM (hCAIX), 6.4 nM (hCAXII)[1]


[References]

[1]. Moi D, et al. Appliance of the piperidinyl-hydrazidoureido linker to benzenesulfonamide compounds: Synthesis, in vitro and in silico evaluation of potent carbonic anhydrase II, IX and XII inhibitors. Bioorg Chem. 2020 May;98:103728.

Chemical & Physical Properties

[ Molecular Formula ]:
C22H27N5O6S

[ Molecular Weight ]:
489.54

Related Compounds