hCAXII-IN-5

Names

[ CAS No. ]:
2414629-92-6

[ Name ]:
hCAXII-IN-5

Biological Activity

[Description]:

hCAXII-IN-5 (compound 6o) is a potent and selective hCAXII inhibitor with Ki values of >10000, >10000, 286.1, 1.0 nM for hCAI, hCAII, hCAIX and hCAXII, respectively[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> Carbonic Anhydrase

[Target]

Ki: >10000 nM (hCAI); >10000 nM (hCAII); 286.1 nM (hCAIX); 1.0 nM (hCAXII)[1].


[References]

[1]. Thacker PS, et al. Design, synthesis and biological evaluation of coumarin linked 1,2,4-oxadiazoles as selective carbonic anhydrase IX and XII inhibitors. Bioorg Chem. 2020 May;98:103739.

Chemical & Physical Properties

[ Molecular Formula ]:
C23H22N2O4

[ Molecular Weight ]:
390.43

Related Compounds