Trametenolic acid

Trametenolic acid is a lanostanol glycoside that isolated from the EtOH extract of the fruit bodies of Laetiporus versisporus[1].

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

ERK1

ERK2

Trametenolic acid (1 mg/mL; 15-30 mins) induces the upregulation of autophagy-related proteins (Beclin-1, Atg12, and LC3) in B16-F1 cells by activating the ERK1/2 signaling pathway[1]. Trametenolic acid (1 mg/mL; 24 hours; B16-F1 cells) has dual synergic mechanisms to exert an anti-melanogenetic effect[1]. Trametenolic acid (0.1-4 mg/mL; 52 hours; B16-F1 cells) increase melanin synthesis by approximately 20% and 40% in cells transfected with siRNAs against mTOR and Atg5, respectively[1]. Western Blot Analysis[1] Cell Line: B16-F1 cells Concentration: 1 mg/mL Incubation Time: 15 and 30 mins Result: Increased the expression levels of phospho-p38, phospho-ERK1/2, Beclin-1, Atg12 and LC3 by approximately 46%, 10%, 48%, 126% and 49%, respectively. Western Blot Analysis[1] Cell Line: B16-F1 cells Concentration: 1 mg/mL Incubation Time: 24 hours Result: Increased the expression of ERK1/2 and p-ERK1/2 and decreased MITF, tyrosinase, and TRP 1 levels.

[1]. K Yoshikawa, et al. New lanostanoid glycosides from the fruit body of laetiporus versisporus. J Nat Prod. 1999 Apr;62(4):543-5.