MAO-B-IN-9

Names

[ Name ]:
MAO-B-IN-9

Biological Activity

[Description]:

MAO-B-IN-9 (compound 16) is a potent, selective, BBB-penetrated, irreversible and time-dependent MAO-B (monoamine oxidase B) inhibitor, with an IC50 of 0.18 μM. MAO-B-IN-9 prevents Aβ1-42-induced neuronal cell death. MAO-B-IN-9 shows neuroprotective effects, which may be the result of its Aβ1-42 anti-aggregation effects[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase

Research Areas >> Neurological Disease

[Target]

MAO-B:0.178 ± 0. μM (IC50)

[References]

[1]. Košak U, et al. N-alkylpiperidine carbamates as potential anti-Alzheimer's agents. Eur J Med Chem. 2020 Jul 1;197:112282.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₂₄N₂O₂

[ Molecular Weight ]:
300.40

MAO-B-IN-9

Names

Biological Activity

Chemical & Physical Properties

Related Compounds