EGFR-IN-68

Names

[ CAS No. ]:
2416925-03-4

[ Name ]:
EGFR-IN-68

Biological Activity

[Description]:

EGFR-IN-68 (Compound 8d) is a potent EGFR inhibitor with an IC50 of 0.33 μM. EGFR-IN-68 shows anticancer activity[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> JAK/STAT Signaling >> EGFR
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR

[In Vitro]

EGFR-IN-68 (Compound 8d) shows cytotoxicity with IC50 values of 3.79 ± 0.04 μM and 25.56 ± 1.59 μM against MCF-7 and WI-38, respectively[1].

[References]

[1]. George RF, et al. Some 1,3,5-trisubstituted pyrazoline derivatives targeting breast cancer: Design, synthesis, cytotoxic activity, EGFR inhibition and molecular docking. Bioorg Chem. 2020 Jun;99:103780.

Chemical & Physical Properties

[ Molecular Formula ]:
C24H22N2O

[ Molecular Weight ]:
354.44

Related Compounds