Enpp-1-IN-13

Names

[ CAS No. ]:
2417022-19-4

[ Name ]:
Enpp-1-IN-13

Biological Activity

[Description]:

Enpp-1-IN-13 (Compound 1a) is an ectonucleotide pyrophosphatase/phosphodiesterase (ENPP) inhibitor with IC50 values of 1.29 μM and 20.2 μM against ENPP1 and ENPP3, respectively. Enpp-1-IN-13 shows anticancer activity[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE)

[Target]

IC50: 1.29 μM (ENPP1), 20.2 μM (ENPP3)[1]


[In Vitro]

Enpp-1-IN-13 (Compound 1a) (100 μM) shows cytotoxic effect with inhibition of 23.0 ± 2.2%, 35.1 ± 0.8% and 30.4 ± 0.1% against HeLa, MCF-7 and 1321N1 cells, respectively[1].

[References]

[1]. Ullah S, et al. Synthesis, biological evaluation, and docking studies of new pyrazole-based thiourea and sulfonamide derivatives as inhibitors of nucleotide pyrophosphatase/phosphodiesterase. Bioorg Chem. 2020 Jun;99:103783.

Chemical & Physical Properties

[ Molecular Formula ]:
C28H22ClN5OS

[ Molecular Weight ]:
512.03

Related Compounds