PROTAC BRD4 Degrader-12

Names

[ Name ]:
PROTAC BRD4 Degrader-12

Biological Activity

[Description]:

PROTAC BRD4 Degrader-12 (compound 9c) is a potent chimeric BRD4 degrader. PROTAC BRD4 Degrader-12 can be conjugated with STEAP1 and CLL1 antibodies to degrade the BRD4 protein in PC3 prostate cancer cells, with a DC50 of 0.39 nM and 0.24 nM, respectively.

Chemical & Physical Properties

[ Molecular Formula ]:
C₆₂H₇₇F₂N₉O₁₂S₄

[ Molecular Weight ]:
1306.58

[ Storage condition ]:
2-8°C

Related Compounds

PROTAC BRD4 Degrader-6
PROTAC BRD4 Degrader-15
PROTAC BRD4 Degrader-10
PROTAC BRD4 Degrader-9
PROTAC BRD4 Degrader-13
PROTAC BRD4 Degrader-2
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2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
(4-Methyl-tetrahydro-furan-2-yl)-methanol
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
tert-Butyl-DL-alanine
4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide
N-[3-(Aminooxy)propyl]-N-butyl-1-butanamine