COX-2-IN-23
Names
[ CAS No. ]:
2417995-08-3
[ Name ]:
COX-2-IN-23
Biological Activity
[Description]:
COX-2-IN-23 (compound 9a) is a selective COX-2 inhibitor with IC50 values of 0.28 and 20.14 μM for COX-2 and COX-1. COX-2-IN-23 has anti-inflammatory activity and low ulcerogenic activity.
[Related Catalog]:
[Target]
COX-2:0.28 μM (IC50)
COX-1:20.14 μM (IC50)
[In Vivo]
COX-2-IN-23 (compound 9a) (9 mg/kg; a single i.p.; 0-4 hours) exhibits anti-inflammatory activities and lowest incidence of pepticulcer[1]. Animal Model: Mature male albino rats[1] Dosage: 9 mg/kg Administration: Intraperitoneal injection; 0, 1, 2, 3 and 4 hours. Result: Had similar ulcerogenic activity to celecoxib.
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C24H25N5O3S2
[ Molecular Weight ]:
495.62