Dihydropteroate synthase-IN-1

Names

[ CAS No. ]:
2418026-70-5

[ Name ]:
Dihydropteroate synthase-IN-1

Biological Activity

[Description]:

Dihydropteroate synthase-IN-1 (compound 5g) is a potent dihydropteroate synthase (DHPS) inhibitor. Dihydropteroate synthase-IN-1 shows antimicrobial activities and antifungal activity. Dihydropteroate synthase-IN-1 inhibits cytochromes P450. Dihydropteroate synthase-IN-1 can bu used as diagnostic radio imaging material[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Bacterial

[Target]

DHPS[1]


[In Vitro]

Dihydropteroate synthase-IN-1 (compound 5g) shows antimicrobial activities with MIC of 24.3, 26.3, 22.8, 20.6, 19.6, 23.2 µg/ml for S. pneumoniae, B. Subtilis, S. epidermidis, E. coli, P. vulgaris, K. pneumonia, respectively[1]. Dihydropteroate synthase-IN-1 shows antifungal activity with MIC of 21.6, 20.3, 20.4 µg/ml for A. fumigates, S. racemosum, G. candidum, respectively[1].

[References]

[1]. Nasr T, et al. New acrylamide-sulfisoxazole conjugates as dihydropteroate synthase inhibitors. Bioorg Med Chem. 2020 May 1;28(9):115444.

Chemical & Physical Properties

[ Molecular Formula ]:
C19H23N5O4S2

[ Molecular Weight ]:
449.55

Related Compounds