FGFR3-IN-1

Names

[ CAS No. ]:
2428743-04-6

[ Name ]:
FGFR3-IN-1

Biological Activity

[Description]:

FGFR3-IN-1 (compound 1) is a fibroblast growth factor receptor (FGFR) inhibitor, with IC50s of 40 nM, 5.1 nM, and 12 nM for FGFR1, 2, and 3, respectively. FGFR3-IN-1 can be used for the research of bladder cancer[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FGFR

[Target]

FGFR1:40 nM (IC50)

FGFR2:5.1 nM (IC50)

FGFR3:12 nM (IC50)


[References]

[1]. Kuriwaki I, et, al. Structure-based drug design of 1,3,5-triazine and pyrimidine derivatives as novel FGFR3 inhibitors with high selectivity over VEGFR2. Bioorg Med Chem. 2020 May 15;28(10):115453.

Chemical & Physical Properties

[ Molecular Formula ]:
C28H39N9O3S

[ Molecular Weight ]:
581.73

Related Compounds