C.I. Direct Blue 15

Names

[ Name ]:
C.I. Direct Blue 15

[Synonym ]:
direct blue
Direct Blue 15
2,7-Naphthalenedisulfonic acid, 3,3'-[(3,3'-dimethoxy[1,1'-biphenyl]-4,4'-diyl)di(Z)-2,1-diazenediyl]bis[5-amino-4-hydroxy-, sodium salt (1:4)
paperblues
EINECS 219-385-3
5,5'-Diamino-4,4'-dihydroxy-3,3'-(3,3'-dimethoxy-biphenyl-4,4'-diylbisazo)-bis-naphthalin-2,7-disulfonsaeure,Natriumsalz
MFCD00036441
airedaleblued
tetrasodium 3,3'-[(3,3'-dimethoxybiphenyl-4,4'-diyl)di(Z)diazene-2,1-diyl]bis(5-amino-4-hydroxynaphthalene-2,7-disulfonate)
Diaminreinblau
C.I. Direct Blue 15
Tetrasodium 3,3'-[(3,3'-dimethoxybiphenyl-4,4'-diyl)di(E)diazene-2,1-diyl]bis(5-amino-4-hydroxynaphthalene-2,7-disulfonate)
directbluehh
Tetrasodium 3,3'-[(3,3'-dimethoxy-4,4'-biphenyldiyl)di(Z)-2,1-diazenediyl]bis(5-amino-4-hydroxy-2,7-naphthalenedisulfonate)
Pontacyl Sky Blue 4BX
skyblue4b
5,5'-diamino-4,4'-dihydroxy-3,3'-(3,3'-dimethoxy-biphenyl-4,4'-diyl-bis-azo)-bis-naphthalene-2,7-disulfonic acid,sodium salt
skyblue5b
modrprima15
LIGHT BLUE
Oxamine Sky Blue
direct sky blue 5B
Direct Sky Blue

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₄H₂₄N₆Na₄O₁₆S₄

[ Molecular Weight ]:
992.804

[ Exact Mass ]:
991.972229

[ PSA ]:
422.72000

[ LogP ]:
10.18560

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QJ6420000

CHEMICAL NAME :: 2,7-Naphthalenedisulfonic acid, 3,3'-((3,3'-dimethoxy-4,4'-biphenylylene)bis(azo))bis ( 5-amino-4-hydroxy-, tetrasodium salt

CAS REGISTRY NUMBER :: 2429-74-5

LAST UPDATED :: 199710

DATA ITEMS CITED :: 19

MOLECULAR FORMULA :: C34-H24-N6-O16-S4.4Na

MOLECULAR WEIGHT :: 992.84

WISWESSER LINE NOTATION :: L66J BQ DSWO HSWO JZ CNUNR CO1 DR BO1 DNUN- CL66J BQ DSWO HSWO JZ &-NA- 4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 52500 mg/kg/14D-C

TOXIC EFFECTS :: Liver - other changes Endocrine - changes in thymus weight Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10 gm/kg/13W

TOXIC EFFECTS :: Liver - fatty liver degeneration Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 168 gm/kg/96W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Brain and Coverings - tumors Blood - leukemia

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 70 mg/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 200 mg/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - eye/ear

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 140 mg/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - other effects to embryo

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 5 gm/kg

SEX/DURATION :: female 8-12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - other postnatal measures or effects

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 100 ug/plate

REFERENCE :: JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year: 18,111,1986 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 57,235,1993 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 57,235,1993 IARC Cancer Review:Group 2B IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 57,235,1993 TOXICOLOGY REVIEW ADTEAS Advances in Teratology. (New York, NY) V.1-5, 1966-72. Discontinued. Volume(issue)/page/year: 1,131,1966 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M4514 No. of Facilities: 10 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 69 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M4514 No. of Facilities: 485 (estimated) No. of Industries: 7 No. of Occupations: 7 No. of Employees: 4527 (estimated) No. of Female Employees: 201 (estimated)

Safety Information

[ Symbol ]:

GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H350

[ Precautionary Statements ]:
P201-P308 + P313

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
R40

[ Safety Phrases ]:
S36

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
QJ6420000

Articles

Chemical-induced atrial thrombosis in NTP rodent studies.

Toxicol. Pathol. 33(5) , 517-32, (2005)

Cardiac thrombosis, one of the causes of sudden death throughout the world, plays a principal role in several cardiovascular diseases, such as myocardial infarction and stroke in humans. Data from stu...

CI Direct Blue 15.

IARC Monogr. Eval. Carcinog. Risks Hum. 57 , 235-45, (1993)

Catalytic wet peroxide oxidation of azo dye (Direct Blue 15) using solvothermally synthesized copper hydroxide nitrate as catalyst.

J. Hazard. Mater. 187(1-3) , 348-54, (2011)

Copper hydroxide nitrate (Cu(2)(OH)(3)NO(3)) was synthesized solvothermally in anhydrous ethanol and characterized by XRD, FTIR, TG-DTA and SEM. The peroxide degradation of an azo dye (Direct Blue 15)...