HDAC6 degrader-1

Names

[ Name ]:
HDAC6 degrader-1

Biological Activity

[Description]:

HDAC6 degrader-1 is a PROTAC that comprises a selective HDAC6 inhibitor Nexturastat A (Nex A) as the HDAC6 binder, a linker and a ligand for recruiting E3 ligase. HDAC6 degrader-1 induces significant degradation of HDAC6, exhibits excellent selectivity against other HDACs, and demonstrates efficient inhibition of cell proliferation[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> PROTAC >> PROTAC

[References]

[1]. An Z, et al. Developing potent PROTACs tools for selective degradation of HDAC6 protein [published correction appears in Protein Cell. 2019 Feb 22;:]. Protein Cell. 2019;10(8):606-609.

Chemical & Physical Properties

[ Molecular Formula ]:
C₄₀H₄₅N₉O₉

[ Molecular Weight ]:
795.84

HDAC6 degrader-1

Names

Biological Activity

Chemical & Physical Properties

Related Compounds