EGFR/HER2/TS-IN-2

Names

[ CAS No. ]:
2444364-04-7

[ Name ]:
EGFR/HER2/TS-IN-2

Biological Activity

[Description]:

EGFR/HER2/TS-IN-2 (compound 17) is a potent EGFR/HER2 and TS (Thymidylate synthase) inhibitor, with IC50 values of 0.173, 0.125, and 1.12 μM, respectively. EGFR/HER2/TS-IN-2 shows cytotoxic activity against MDA-MB-231 cancer cell lines, with an IC50 of 1.69 µM[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Thymidylate Synthase
Research Areas >> Cancer
Signaling Pathways >> JAK/STAT Signaling >> EGFR
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR

[Target]

EGFR:0.173 ± 0. μM (IC50)

HER2:0.125 ± 0. μM (IC50)


[In Vitro]

EGFR/HER2/TS-IN-2 (compound 17) shows the GI (growth inhibition)=53.20 and 49.35% towards ovarian cancer IGROV1 and renal cancer UO-31, respectively[1].

[References]

[1]. Abdellatif KRA, et al. Design, synthesis, molecular docking and antiproliferative activity of some novel benzothiazole derivatives targeting EGFR/HER2 and TS. Bioorg Chem. 2020 Aug;101:103976.

Chemical & Physical Properties

[ Molecular Formula ]:
C26H21N7OS2

[ Molecular Weight ]:
511.62

Related Compounds