Keap1-Nrf2-IN-10

Names

[ CAS No. ]:
2445349-54-0

[ Name ]:
Keap1-Nrf2-IN-10

Biological Activity

[Description]:

Keap1-Nrf2-IN-10 (compound 15) is a potent NQO1 inducer. Keap1-Nrf2-IN-10 inhibits oxidative stress by decreasing the levels of MDA, ROS, NQO1 in the liver for gamma-irradiated mice. Keap1-Nrf2-IN-10 improves the survival of gamma-irradiated mice[1].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Others >> Others

[Target]

NQO1[1]


[References]

[1]. Soliman AM, et al. Radiomodulatory effect of a non-electrophilic NQO1 inducer identified in a screen of new 6, 8-diiodoquinazolin-4(3H)-ones carrying a sulfonamide moiety. Eur J Med Chem. 2020 Aug 15;200:112467.

Chemical & Physical Properties

[ Molecular Formula ]:
C25H22I2N4O7S2

[ Molecular Weight ]:
808.40

Related Compounds