Pomalidomide-C7-NH2 hydrochloride

Names

[ Name ]:
Pomalidomide-C7-NH2 hydrochloride

[Synonym ]:
1H-Isoindole-1,3(2H)-dione, 4-[(7-aminoheptyl)amino]-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1)
4-[(7-Aminoheptyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione hydrochloride
4-[(7-Aminoheptyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione hydrochloride (1:1)

Biological Activity

[Description]:

Pomalidomide-C7-NH2 (Pomalidomide 4'-alkylC7-amine) hydrochloride is an E3 ligase ligand-linker conjugate. Pomalidomide-C7-NH2 hydrochloride can be used for the synthesis of PROTAC[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate

[References]

[1]. Li Y, et al. Discovery of MD-224 as a First-in-Class, Highly Potent, and Efficacious Proteolysis Targeting Chimera Murine Double Minute 2 Degrader Capable of Achieving Complete and Durable Tumor Regression. J Med Chem. 2019 Jan 24;62(2):448-466.

[2]. Si Woo Choi, et al. Hmg-coa reductase degradation inducing compound. Patent, WO2021201577A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₂₇ClN₄O₄

[ Molecular Weight ]:
422.91

[ Exact Mass ]:
422.172089