Taragarestrant meglumine

Names

[ CAS No. ]:
2446618-18-2

[ Name ]:
Taragarestrant meglumine

Biological Activity

[Description]:

Taragarestrant (D-0502) meglumine is a potent, orally active and selective estrogen receptor degrader (SERD). Taragarestrant meglumine shows potent activity in various ER+ breast cancer cell lines and xenograft models[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Estrogen Receptor/ERR
Research Areas >> Cancer

[In Vivo]

Taragarestrant (D-0502) exhibits superior PK profiles suitable for clinical development[1].

[References]

[1]. Lin WY, et, al. Abstract 5776: Pharmacologic and PK/PD study of D-0502: An orally bioavailable SERD with potent antitumor activity in ER-positive breast cancer cell lines and xenograft models. 2018 Jul 1;78(13):5776.

[2]. WHO Drug Information. International Nonproprietary Names for Pharmaceutical.

Chemical & Physical Properties

[ Molecular Formula ]:
C32H42Cl2FN3O7

[ Molecular Weight ]:
670.60

Related Compounds