COX-2-IN-22

Names

[ CAS No. ]:
2447589-08-2

[ Name ]:
COX-2-IN-22

Biological Activity

[Description]:

COX-2-IN-22 (Compound 4h) is a COX-2 inhibitor with an IC50 of 8.6 µM. COX-2-IN-22 also inhibits AChE, BChE, β-Secretase, LOX-5 and DPPH with IC50 values of 2.8, 6.3, 15.3, 13.9 and 6.8 µM, respectively. COX-2-IN-22 can cross BBB[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Beta-secretase
Research Areas >> Inflammation/Immunology
Signaling Pathways >> Immunology/Inflammation >> COX
Research Areas >> Neurological Disease
Signaling Pathways >> Neuronal Signaling >> AChE

[Target]

COX-2:8.6 μM (IC50)

AChE:2.8 μM (IC50)

BChE:6.3 μM (IC50)

β-Secretase:15.3 μM (IC50)

LOX-5:13.9 μM (IC50)

DPPH:6.8 μM (IC50)


[References]

[1]. Agbo EN, et al. Synthesis of furocoumarin-stilbene hybrids as potential multifunctional drugs against multiple biochemical targets associated with Alzheimer's disease. Bioorg Chem. 2020 Aug;101:103997.

Chemical & Physical Properties

[ Molecular Formula ]:
C29H24O7

[ Molecular Weight ]:
484.50

Related Compounds