GlcN-6-P Synthase-IN-1

Names

[ CAS No. ]:
2447602-44-8

[ Name ]:
GlcN-6-P Synthase-IN-1

Biological Activity

[Description]:

GlcN-6-P Synthase-IN-1 (Compound 4d) is a Glucosamine-6-phosphate (GlcN-6-P) synthase inhibitor with an IC50 of 3.47 μM. GlcN-6-P Synthase-IN-1 exhibits significant antimicrobial activity. GlcN-6-P Synthase-IN-1 has good penetration in the CNS and is able to inhibit the cytochrome P450, CYP3A4 isoform[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450
Signaling Pathways >> Anti-infection >> Fungal
Signaling Pathways >> Anti-infection >> Bacterial

[Target]

IC50: 3.47 μM (GlcN-6-P synthase)[1]


[In Vitro]

GlcN-6-P Synthase-IN-1 (Compound 4d) shows antimicrobial activity with MIC values of 1 ± 0.15, 0.5 ± 0.15, 4 ± 0.33 and 4 ± 0.33 µg/mL against S. aureus, B. subtilis, C. albicans and A. oryzae, respectively[1].

[References]

[1]. Omar AM, et al. The rational design, synthesis, and antimicrobial investigation of 2-Amino-4-Methylthiazole analogues inhibitors of GlcN-6-P synthase. Bioorg Chem. 2020 Jun;99:103781.

Chemical & Physical Properties

[ Molecular Formula ]:
C20H21N7S

[ Molecular Weight ]:
391.49

Related Compounds