Galanin-Like Peptide (porcine) trifluoroacetate salt

Names

[ Name ]:
Galanin-Like Peptide (porcine) trifluoroacetate salt

Biological Activity

[Description]:

Galanin-Like Peptide (porcine) is a 60 amino acid neuropeptide that was first isolated from the porcine hypothalamus. Galanin-Like Peptide (porcine) has a high affinity for the GALR2 receptor (IC50 of 0.24 nM) and a lower affinity for the GALR1 receptor (IC50 of 4.3 nM)[1].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> Neuropeptide Y Receptor

[References]

[1]. T Ohtaki, et al. Isolation and cDNA cloning of a novel galanin-like peptide (GALP) from porcine hypothalamus. J Biol Chem. 1999 Dec 24;274(52):37041-5.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₈₁H₄₄₃N₈₁O₇₈

[ Molecular Weight ]:
6204.1

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Articles

Galanin modulates the neural niche to favour perineural invasion in head and neck cancer.

Nat. Commun. 6 , 6885, (2015)

Perineural invasion (PNI) is an indicator of poor survival in multiple cancers. Unfortunately, there is no targeted treatment for PNI since the molecular mechanisms are largely unknown. PNI is an acti...

Galanin-like peptides exert potent vasoactive functions in vivo.

J. Invest. Dermatol. 127(3) , 716-21, (2007)

The cutaneous vasculature plays a key role in the pathophysiology of inflammatory skin diseases. The vascular activity is under the control of the peripheral nervous system that includes locally relea...

Cloning and distribution of galanin-like peptide mRNA in the hypothalamus and pituitary of the macaque.

Endocrinology 143(3) , 755-63, (2002)

Galanin-like peptide (GALP) is a newly discovered hypothalamic neuropeptide, which is regulated by leptin and implicated in the regulation of GnRH secretion in the rodent. We searched the human genome...