Ozenoxacin

Names

[ Name ]:
Ozenoxacin

[Synonym ]:
T 3912
UNII-V0LH498RFO
1-Cyclopropyl-8-methyl-7-[5-methyl-6-(methylamino)-3-pyridinyl]-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid
Ozenoxacin (JAN/INN)
3-Quinolinecarboxylic acid, 1-cyclopropyl-1,4-dihydro-8-methyl-7-[5-methyl-6-(methylamino)-3-pyridinyl]-4-oxo-
ozenoxacin

Biological Activity

[Description]:

Ozenoxacin is a nonfluorinated quinolone antibacterial, which shows potent activities against the main microorganisms isolated from skin and soft tissue infections.

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Bacterial

Research Areas >> Infection

[Target]

Bacterial[1]

[In Vitro]

Ozenoxacin (OZN) shows potent antibacterial activities against clinical isolates of Gram-positive microorganisms, with MICs ranging from 0.008 to 4 mg/L. Ozenoxacin shows good activities against strains of MRSA, MSSA, MSSE, and MRSE with 2, 3, or 4 mutations in the gyrA and grlA (parC) genes[1]. Ozenoxacin inhibits MSSA strains and S. agalactiae strains, with the rates of resistance of >10−10 and 5.3 × 10−10, respectively. The maximum MIC value for mutant strains is 8 mg/L for ozenoxacin[2].

[References]

[1]. López Y, et al. In vitro activity of Ozenoxacin against quinolone-susceptible and quinolone-resistant gram-positive bacteria. Antimicrob Agents Chemother. 2013 Dec;57(12):6389-92.

[2]. López Y, et al. In vitro selection of mutants resistant to ozenoxacin compared with levofloxacin and ciprofloxacin in Gram-positive cocci. J Antimicrob Chemother. 2015 Jan;70(1):57-61

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
573.5±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₁H₂₁N₃O₃

[ Molecular Weight ]:
363.410

[ Flash Point ]:
300.7±30.1 °C

[ Exact Mass ]:
363.158295

[ PSA ]:
87.45000

[ LogP ]:
3.41

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.694

[ Storage condition ]:
2-8℃