4-HYDROXYWARFARIN
Names
[ CAS No. ]:
24579-14-4
[ Name ]:
4-HYDROXYWARFARIN
[Synonym ]:
4-Hydroxywarfarin
4'-Hydroxywarfarin
Chemical & Physical Properties
[ Density]:
1.384g/cm3
[ Boiling Point ]:
522ºC at 760mmHg
[ Molecular Formula ]:
C19H16O5
[ Molecular Weight ]:
324.32700
[ Flash Point ]:
190.3ºC
[ Exact Mass ]:
324.10000
[ PSA ]:
87.74000
[ LogP ]:
3.31520
[ Vapour Pressure ]:
1E-11mmHg at 25°C
[ Index of Refraction ]:
1.658
MSDS
Safety Information
[ Symbol ]:
GHS05, GHS07
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H302-H318
[ Precautionary Statements ]:
P280-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves
[ Hazard Codes ]:
Xn: Harmful;
[ Risk Phrases ]:
22-41
[ Safety Phrases ]:
26-39
[ RIDADR ]:
NONH for all modes of transport
[ HS Code ]:
2914501900
Synthetic Route
Customs
[ HS Code ]: 2914501900
[ Summary ]:
2914501900 other ketone-phenols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%
Articles
Chem. Res. Toxicol. 23(5) , 939-45, (2010)
Coumadin (R/S-warfarin) anticoagulant therapy poses a risk to over 50 million Americans, in part due to interpersonal variation in drug metabolism. Consequently, it is important to understand how meta...
Metabolism of R- and S-warfarin by CYP2C19 into four hydroxywarfarins.Drug Metab. Lett. 6(3) , 157-64, (2012)
Coumadin (R/S-warfarin) is a highly efficacious and widely used anticoagulant; however, its highly variable metabolism remains an important contributor to uncertainties in therapeutic responses. Pharm...
Contribution of three CYP3A isoforms to metabolism of R- and S-warfarin.Drug Metab. Lett. 4(4) , 213-9, (2010)
Effective coumadin (R/S-warfarin) therapy is complicated by inter-individual variability in metabolism. Recent studies have demonstrated that CYP3A isoforms likely contribute to patient responses and ...